Chytyk K, McCurdy B M C
Division of Medical Physics, CancerCare Manitoba, 675 McDermot Avenue, Winnipeg, Manitoba R3E 0V9, Canada.
Med Phys. 2006 Sep;33(9):3333-9. doi: 10.1118/1.2259819.
The effect of beam divergence on dose calculation via Monte Carlo generated dose kernels was investigated in an amorphous silicon electronic portal imaging device (EPID). The flat-panel detector was simulated in EGSnrc with an additional 3.0 cm water buildup. The model included details of the detector's imaging cassette and the front cover upstream of it. To approximate the effect of the EPID's rear housing, a 2.1 cm air gap and 1.0 cm water slab were introduced into the simulation as equivalent backscatter material. Dose kernels were generated with an incident pencil beam of monoenergetic photons of energy 0.1, 2, 6, and 18 MeV. The orientation of the incident pencil beam was varied from 0 degrees to 14 degrees in 2 degrees increments. Dose was scored in the phosphor layer of the detector in both cylindrical (at 0 degrees) and Cartesian (at 0 degrees - 14 micro) geometries. To reduce statistical fluctuations in the Cartesian geometry simulations at large radial distances from the incident pencil beam, the voxels were first averaged bilaterally about the pencil beam and then combined into concentric square rings of voxels. Profiles of the EPID dose kernels displayed increasing asymmetry with increasing angle and energy. A comparison of the superposition (tilted kernels) and convolution (parallel kernels) dose calculation methods via the chi-comparison test (a derivative of the gamma-evaluation) in worst-case-scenario geometries demonstrated an agreement between the two methods within 0.0784 cm (one pixel width) distance-to-agreement and up to a 1.8% dose difference. More clinically typical field sizes and source-to-detector distances were also tested, yielding at most a 1.0% dose difference and the same distance-to-agreement. Therefore, the assumption of parallel dose kernels has less than a 1.8% dosimetric effect in extreme cases and less than a 1.0% dosimetric effect in most clinically relevant situations and should be suitable for most clinical dosimetric applications. The resulting time difference for the parallel kernel assumption versus the tilted kernels was 10.5 s vs 18 h (a factor of approximately 6000), dependent on existing hardware and software details.
在非晶硅电子射野影像装置(EPID)中,研究了射束发散对通过蒙特卡罗生成的剂量核进行剂量计算的影响。在EGSnrc中对平板探测器进行了模拟,并额外增加了3.0 cm的水等效厚度。该模型包括探测器成像暗盒及其上游前盖的细节。为了近似EPID后壳的影响,在模拟中引入了2.1 cm的气隙和1.0 cm的水等效层作为等效背散射材料。使用能量为0.1、2、6和18 MeV的单能光子入射笔形束生成剂量核。入射笔形束的方向以2度增量从0度变化到14度。在探测器的磷光层中,在圆柱几何形状(0度)和笛卡尔几何形状(0度 - 14度)下对剂量进行评分。为了减少笛卡尔几何形状模拟中在距入射笔形束较大径向距离处的统计波动,首先将体素围绕笔形束进行双边平均,然后组合成同心的方形体素环。EPID剂量核的剖面图显示,随着角度和能量的增加,不对称性增加。在最坏情况几何形状下,通过卡方比较测试(伽马评估的导数)对叠加(倾斜核)和卷积(平行核)剂量计算方法进行比较,结果表明两种方法在0.0784 cm(一个像素宽度)的距离一致性内以及高达1.8%的剂量差异内达成一致。还测试了更具临床代表性的射野大小和源到探测器距离,产生的最大剂量差异为1.0%,距离一致性相同。因此,在极端情况下,平行剂量核的假设具有小于1.8%的剂量学效应,在大多数临床相关情况下具有小于1.0%的剂量学效应,并且应该适用于大多数临床剂量学应用。平行核假设与倾斜核假设产生的时间差分别为10.5秒和18小时(约6000倍),这取决于现有的硬件和软件细节。