Pujal Herranz M, Roca Massa M, Domínguez Tordera P, Codina Jané C, Ribas Sala J
Servicio de Farmacia, Hospital Clínic, Barcelona.
Farm Hosp. 2006 Jul-Aug;30(4):254-9. doi: 10.1016/s1130-6343(06)73984-8.
To present a protocol for the administration and development technique of the desensitization regimens for cotrimoxazole, rifampicin and penicillin G hypersensibility.
A review of the available desensitization protocols for these antibiotics and a retrospective study of desensitization processes undertaken in the center from 1998. A development technique of the antibiotic dosages was designed.
Desensitization regimens for cotrimoxazole, rifampicin and penicillin G undertaken in the center in 9 patients came from a protocol by Glucksteins et al., Holland et al. and Wendal et al., respectively. After the literature review and the satisfactory results that allowed subsequent antibiotic administration in the 9 cases, these regimens were established as protocols of the center.
Dosage development and patient administration have a practical application and can help to decrease the potential mistakes related to the complexity of the process.
提出一种针对复方新诺明、利福平及青霉素G过敏的脱敏治疗方案及给药和制定技术。
回顾这些抗生素现有的脱敏方案，并对该中心1998年以来进行的脱敏过程进行回顾性研究。设计了抗生素剂量的制定技术。
该中心对9例患者进行的复方新诺明、利福平及青霉素G脱敏治疗方案分别来自格鲁克斯坦等人、霍兰德等人和温德尔等人的方案。经文献回顾及9例患者后续抗生素给药取得满意效果后，这些方案被确立为该中心的方案。
剂量制定及患者给药具有实际应用价值，有助于减少因过程复杂而可能出现的错误。
