从儿科血液学/肿瘤学患者的口咽标本和血培养物中分离出的念珠菌属对氟康唑和伊曲康唑的敏感性。

Fluconazole and itraconazole susceptibilities of Candida spp. isolated from oropharyngeal specimens and blood cultures of paediatric haematology/oncology patients.

作者信息

Kennedy H F, Shankland G S, Bagg J, Chalmers E A, Gibson B E S, Williams C L

机构信息

Department of Microbiology, Royal Hospital for Sick Children, Yorkhill Division, Glasgow, UK.

出版信息

Mycoses. 2006 Nov;49(6):457-62. doi: 10.1111/j.1439-0507.2006.01272.x.

DOI:10.1111/j.1439-0507.2006.01272.x

PMID:17022761

Abstract

This study examined the in vitro susceptibilities to fluconazole and itraconazole of isolates of Candida spp. from surveillance oropharyngeal specimens and blood cultures from paediatric patients with malignancy. The species distribution of 100 isolates from oropharyngeal specimens was C. albicans 86%, C. glabrata 7%, C. lusitaniae 4%, C. parapsilosis 2% and C. tropicalis 1%. From a total of nine isolates from blood cultures the species distribution was C. albicans 33.3%, C. parapsilosis 33.3 % and C. guilliermondii 33.3%. Only three of the oropharyngeal isolates were resistant to fluconazole (MIC > or = 64 mg l(-1)) and only two were resistant to itraconazole (MIC > or = 1 mg l(-1)). None of the blood culture isolates was resistant to either agent. At this centre, C. albicans is the predominant species from oropharyngeal specimens, but non-albicans Candida species predominate in blood cultures. Although resistance to fluconazole and itraconazole is rare at present, continued surveillance is warranted to monitor trends in species distribution and antifungal susceptibility.

摘要

本研究检测了来自恶性肿瘤患儿监测口咽标本和血培养的念珠菌属分离株对氟康唑和伊曲康唑的体外敏感性。100株口咽标本分离株的菌种分布为：白色念珠菌86%、光滑念珠菌7%、葡萄牙念珠菌4%、近平滑念珠菌2%、热带念珠菌1%。在总共9株血培养分离株中，菌种分布为：白色念珠菌33.3%、近平滑念珠菌33.3%、季也蒙念珠菌33.3%。仅3株口咽分离株对氟康唑耐药（MIC≥64 mg l(-1)），仅2株对伊曲康唑耐药（MIC≥1 mg l(-1)）。血培养分离株均对这两种药物不耐药。在该中心，白色念珠菌是口咽标本中的主要菌种，但非白色念珠菌在血培养中占主导地位。尽管目前对氟康唑和伊曲康唑的耐药情况少见，但仍需持续监测以监测菌种分布和抗真菌药敏的趋势。