Liu Y, Nuutinen J, Laakso M P, Karonen J O, Soimakallio S, Aronen H J, Vanninen R L
Department of Clinical Radiology, Kuopio University Hospital, Kuopio, Finland.
Acta Neurol Scand. 2006 Nov;114(5):323-8. doi: 10.1111/j.1600-0404.2006.00654.x.
We examined whether the apolipoprotein E (ApoE) allele epsilon4 influences imaging findings in stroke as assessed by diffusion- (DWI) and perfusion-weighted (PWI) magnetic resonance imaging, and MR angiography (MRA).
Eight ApoE epsilon4 carriers and 15 non-carriers with acute ischemic stroke in the anterior circulation underwent DWI, PWI, and MRA within 24 h of stroke. DWI and PWI were repeated a week later. The apparent diffusion coefficient, relative cerebral volume (rCBV), relative cerebral blood flow (rCBF) and relative mean transit time were measured in three subregions on day one.
In the ischemic core and the area of infarct growth, rCBV values were significantly higher in the epsilon4 carriers compared with the non-carriers. Based on the MRA findings, collateral blood flow was better in the epsilon4 carriers than in the non-carriers. Under the comparable severity of hypoperfusion, the hypoperfused area proceeded to infarction later or did not proceed to infarction at all in the non-carriers.
These preliminary data suggest that in the ApoE allele epsilon4 carriers the threshold for the brain tissue to survive hypoperfusion versus to proceed to infarction seems to be different from that of the non-carriers.
我们研究了载脂蛋白E（ApoE）ε4等位基因是否会影响通过扩散加权（DWI）、灌注加权（PWI）磁共振成像以及磁共振血管造影（MRA）评估的中风影像学表现。
8名携带ApoE ε4等位基因者和15名非携带者发生前循环急性缺血性中风，在中风后24小时内接受了DWI、PWI和MRA检查。一周后重复进行DWI和PWI检查。在第一天测量三个亚区域的表观扩散系数、相对脑血容量（rCBV）、相对脑血流量（rCBF）和相对平均通过时间。
在缺血核心区和梗死生长区域，与非携带者相比，ε4等位基因携带者的rCBV值显著更高。根据MRA结果，ε4等位基因携带者的侧支血流比非携带者更好。在灌注不足严重程度相当的情况下，非携带者中灌注不足区域发展为梗死的时间更晚或根本未发展为梗死。
这些初步数据表明，在ApoE ε4等位基因携带者中，脑组织在灌注不足时存活与发展为梗死的阈值似乎与非携带者不同。
