Zarrindast Mohammad-Reza, Ebrahimi Maliheh, Khalilzadeh Azita
Department of Pharmacology and Iranian National Center for Addiction Studies, Tehran University of Medical Sciences, Tehran, Iran.
Eur J Pharmacol. 2006 Nov 21;550(1-3):107-11. doi: 10.1016/j.ejphar.2006.08.042. Epub 2006 Sep 7.
The effects of ATP-sensitive potassium channels on lithium induced state-dependent memory of passive avoidance task were examined in mice. The pre-training (5 mg/kg) and pre-test (5 mg/kg) injection of lithium impaired memory retrieval on the test day. Impairment of pre-training lithium was restored by pre-test administration of lithium (5 mg/kg), diazoxide, an ATP-sensitive potassium channel opener, (15, 30 and 60 mg/kg) or glibenclamide, an ATP-sensitive potassium channel blocker, (6 and 18 mg/kg). Pre-test administration of inactive doses of lithium (2.5 and 10 mg/kg) plus lower and inactive dose of glibenclamide (2 mg/kg) or diazoxide (1.5 mg/kg) also reversed the amnesia induced by pre-training lithium (5 mg/kg). In conclusion, the ATP-sensitive potassium channel opener or blocker not only mimicked the effect of lithium in state-dependent learning in the absence of lithium on the test day, but also potentiated the effect of low dose of lithium in restoration of memory. Therefore, ATP-sensitive potassium channels may have a modulatory influence on lithium response.
在小鼠中研究了ATP敏感性钾通道对锂诱导的被动回避任务状态依赖性记忆的影响。训练前（5毫克/千克）和测试前（5毫克/千克）注射锂会损害测试当天的记忆恢复。测试前给予锂（5毫克/千克）、二氮嗪（一种ATP敏感性钾通道开放剂，剂量为15、30和60毫克/千克）或格列本脲（一种ATP敏感性钾通道阻滞剂，剂量为6和18毫克/千克）可恢复训练前锂造成的损害。测试前给予无活性剂量的锂（2.5和10毫克/千克）加上较低且无活性剂量的格列本脲（2毫克/千克）或二氮嗪（1.5毫克/千克）也可逆转训练前锂（5毫克/千克）诱导的失忆。总之，ATP敏感性钾通道开放剂或阻滞剂不仅在测试当天无锂的情况下模拟了锂在状态依赖性学习中的作用，还增强了低剂量锂恢复记忆方面的作用。因此，ATP敏感性钾通道可能对锂反应具有调节作用。
