Colombo Giancarlo, Serra Salvatore, Vacca Giovanni, Carai Mauro A M, Gessa Gian Luigi
C.N.R. Institute of Neuroscience, Cagliari, Italy.
Eur J Pharmacol. 2006 Nov 21;550(1-3):123-6. doi: 10.1016/j.ejphar.2006.08.052. Epub 2006 Sep 8.
This study investigated the effect of the gamma-aminobutyric acid(B) (GABA(B)) receptor agonist, baclofen, on alcohol deprivation effect (the transient increase in alcohol intake occurring after a period of alcohol abstinence) in Sardinian alcohol-preferring (sP) rats exposed to 4 bottles containing water and 10%, 20%, and 30% (v/v) alcohol, respectively. Acute administration of baclofen (1 mg/kg, i.p.) suppressed both aspects of alcohol deprivation effect: the extra-intake of alcohol and the selection of the highest concentrated alcohol solution. These results suggest that the GABA(B) receptor is part of the neural substrate mediating alcohol deprivation in sP rats.
本研究调查了γ-氨基丁酸B（GABA(B)）受体激动剂巴氯芬对撒丁岛嗜酒（sP）大鼠戒酒效应（一段戒酒期后酒精摄入量短暂增加）的影响，这些大鼠接触分别装有水、10%、20%和30%（v/v）酒精的4个瓶子。急性给予巴氯芬（1毫克/千克，腹腔注射）可抑制戒酒效应的两个方面：酒精额外摄入量以及对最高浓度酒精溶液的选择。这些结果表明，GABA(B)受体是介导sP大鼠戒酒的神经基质的一部分。
