Scurry J
Department of Anatomical Pathology, Monash Medical Centre, Clayton, Victoria, Australia.
J Paediatr Child Health. 1990 Oct;26(5):280-2. doi: 10.1111/j.1440-1754.1990.tb01072.x.
Intramucosal ganglion cells are commonly believed not to occur in normal colon and to be found only in the chronic bowel motility disorder, neuronal intestinal dysplasia. After chance observations of two intramucosal ganglion cells in endoscopic biopsies in two patients without neuronal intestinal dysplasia, a retrospective study was undertaken to determine how frequently ganglion cells are present in colonic mucosa. Excluding the index cases, three intramucosal ganglion cells were found in 169 consecutive colonic biopsies. The nature of the ganglion cells was confirmed by positive neurone specific enolase staining by the peroxidase-antiperoxidase technique in all cases. None of the patients had neuronal intestinal dysplasia. The diagnosis of neuronal intestinal dysplasia should rely on a constellation of clinicopathological features. Rare intramucosal ganglion cells are a normal histological finding.
通常认为黏膜内神经节细胞在正常结肠中不会出现，仅在慢性肠道动力障碍即神经源性肠发育异常中存在。在偶然观察到两名无神经源性肠发育异常的患者内镜活检中有两个黏膜内神经节细胞后，开展了一项回顾性研究，以确定结肠黏膜中神经节细胞出现的频率。排除索引病例后，在169例连续的结肠活检中发现了三个黏膜内神经节细胞。所有病例中通过过氧化物酶-抗过氧化物酶技术进行的神经元特异性烯醇化酶阳性染色证实了神经节细胞的性质。所有患者均无神经源性肠发育异常。神经源性肠发育异常的诊断应依赖一系列临床病理特征。罕见的黏膜内神经节细胞是一种正常的组织学表现。
