钙激动剂BAY K 8644在恶性高热易感性体外诊断中的应用。

Use of the calcium agonist BAY K 8644 for in vitro diagnosis of susceptibility to malignant hyperthermia.

作者信息

Adnet P J, Krivosic-Horber R M, Haudecoeur G, Adamantidis M M, Reyford G H, Imbenotte M, Cordonnier C

机构信息

Département d'Anesthésie-Réanimation Chirurgicale, Faculté de Pharmacie, Centre Hospitalier Universitaire, Lille, France.

出版信息

Br J Anaesth. 1990 Dec;65(6):791-5. doi: 10.1093/bja/65.6.791.

DOI:10.1093/bja/65.6.791

PMID:1702303

Abstract

We have studied the effects of the calcium agonist BAY K 8644 on the in vitro halothane test in 10 malignant hyperthermia-susceptible (MHS), 12 MH "equivocal" to halothane (MHEh), 30 MH non-susceptible (MHN) and 10 control patients. BAY K 8644 potentiated the halothane-induced contracture in muscle strips from both MHS and MHEh patients. The drug produced a more obvious difference in contracture responses between the MHEh group compared with the MHN and control groups.

摘要

我们研究了钙激动剂BAY K 8644对10例恶性高热易感（MHS）患者、12例对氟烷呈“可疑”恶性高热（MHEh）患者、30例恶性高热非易感（MHN）患者及10例对照患者的体外氟烷试验的影响。BAY K 8644增强了MHS和MHEh患者肌肉条带中氟烷诱导的挛缩。与MHN组和对照组相比，该药物在MHEh组的挛缩反应中产生了更明显的差异。