Dolman Nick J, Tepikin Alexei V
The Physiological Laboratory, The University of Liverpool, Crown Street, Liverpool, UK.
Cell Calcium. 2006 Nov-Dec;40(5-6):505-12. doi: 10.1016/j.ceca.2006.08.012. Epub 2006 Oct 4.
Changes in intracellular free calcium regulate many intracellular processes. With respect to the secretory pathway and the Golgi apparatus, changes in calcium concentration occurring either in the adjacent cytosol or within the lumen of the Golgi act to regulate Golgi function. Conversely, the Golgi sequesters calcium to shape cytosolic calcium signals as well as initiate them by releasing calcium via inositol-1,4,5-triphosphate (IP(3)) receptors, located on Golgi membranes. Local calcium transients juxtaposed to the Golgi (arising from release by the Golgi or other organelles) can activate calcium dependent signalling molecules located on or around the Golgi. This review focuses on the reciprocal relationship between the cell biology of the Golgi apparatus and intracellular calcium homeostasis.
细胞内游离钙的变化调节许多细胞内过程。就分泌途径和高尔基体而言，相邻细胞质或高尔基体腔内发生的钙浓度变化可调节高尔基体功能。相反，高尔基体隔离钙以塑造细胞质钙信号，并通过位于高尔基体膜上的肌醇-1,4,5-三磷酸（IP(3)）受体释放钙来启动这些信号。与高尔基体并列的局部钙瞬变（由高尔基体或其他细胞器释放产生）可激活位于高尔基体上或其周围的钙依赖性信号分子。本综述重点关注高尔基体的细胞生物学与细胞内钙稳态之间的相互关系。
