正电子发射断层扫描显示纤维肌痛综合征患者突触前多巴胺活性降低：一项初步研究。

Reduced presynaptic dopamine activity in fibromyalgia syndrome demonstrated with positron emission tomography: a pilot study.

作者信息

Wood Patrick B, Patterson James C, Sunderland John J, Tainter Kerrie H, Glabus Michael F, Lilien David L

机构信息

Department of Family Medicine and Anesthesiology, Louisiana State University Health Sciences Center-Shreveport, Shreveport, LA 71103, USA.

出版信息

J Pain. 2007 Jan;8(1):51-8. doi: 10.1016/j.jpain.2006.05.014. Epub 2006 Oct 4.

DOI:10.1016/j.jpain.2006.05.014

PMID:17023218

Abstract

UNLABELLED

Although the pathophysiology underlying the pain of fibromyalgia syndrome (FMS) remains unknown, a variety of clinical and investigational findings suggests a dysregulation of dopaminergic neurotransmission. We therefore investigated presynaptic dopaminergic function in 6 female FMS patients in comparison to 8 age- and gender-matched controls as assessed by positron emission tomography with 6-[(18)F]fluoro-L-DOPA as a tracer. Semiquantitative analysis revealed reductions in 6-[(18)F]fluoro-L-DOPA uptake in several brain regions, indicating a disruption of presynaptic dopamine activity wherein dopamine plays a putative role in natural analgesia. Although the small sample size makes these findings preliminary, it appears that FMS might be characterized by a disruption of dopaminergic neurotransmission.

PERSPECTIVE

An association between FMS and reduced dopamine metabolism within the pain neuromatrix provides important insights into the pathophysiology of this mysterious disorder.

摘要

未标记

尽管纤维肌痛综合征（FMS）疼痛背后的病理生理学仍不清楚，但各种临床和研究结果表明多巴胺能神经传递失调。因此，我们以6-[(18)F]氟-L-多巴为示踪剂，通过正电子发射断层扫描评估了6名女性FMS患者与8名年龄和性别匹配的对照者的突触前多巴胺能功能。半定量分析显示，几个脑区的6-[(18)F]氟-L-多巴摄取减少，表明突触前多巴胺活性受到破坏，其中多巴胺在自然镇痛中可能起作用。尽管样本量小使得这些发现具有初步性，但似乎FMS可能以多巴胺能神经传递破坏为特征。