Hatziioannou Theodora, Princiotta Michael, Piatak Michael, Yuan Fang, Zhang Fengwen, Lifson Jeffrey D, Bieniasz Paul D
Aaron Diamond AIDS Research Center and Rockefeller University, 455 First Avenue, New York, NY 10016, USA.
Science. 2006 Oct 6;314(5796):95. doi: 10.1126/science.1130994.
Because HIV-1 does not infect most nonhuman primates, animal modeling of human HIV infection and AIDS has primarily consisted of experimentally infecting macaques with related simian immunodeficiency viruses (SIVMAC). However, the usefulness of such models is limited by the substantial divergence between SIVMAC and HIV-1. We derived an HIV-1-based virus that includes only small portions of SIVMAC yet replicates robustly in both transformed and primary rhesus macaque T cells. Derivation of simian-tropic HIV-1 (stHIV-1) has important implications for understanding primate lentivirus zoonosis and should allow the development of improved animal models for studies of AIDS and the evaluation of vaccines and treatments.
由于HIV-1不会感染大多数非人类灵长类动物，人类HIV感染和艾滋病的动物模型主要是通过用相关的猴免疫缺陷病毒（SIVMAC）对猕猴进行实验性感染来构建的。然而，这类模型的实用性受到SIVMAC与HIV-1之间巨大差异的限制。我们获得了一种基于HIV-1的病毒，它仅包含一小部分SIVMAC，但能在转化的和原代恒河猴T细胞中强劲复制。猿嗜性HIV-1（stHIV-1）的获得对于理解灵长类慢病毒人畜共患病具有重要意义，并且应该能够推动开发用于艾滋病研究以及疫苗和治疗评估的改良动物模型。
