Mendenhall William M, Mendenhall Charles M, Werning John W, Reith John D, Mendenhall Nancy P
Department of Radiation Oncology, University of Florida College of Medicine, Gainesville, FL, USA.
Am J Clin Oncol. 2006 Oct;29(5):524-8. doi: 10.1097/01.coc.0000227544.01779.52.
To discuss the treatment and outcomes for cutaneous angiosarcoma.
Review of the pertinent literature.
Cutaneous angiosarcoma is a rare, aggressive malignancy with a poor prognosis. It usually arises in the scalp or face and is locally advanced at presentation. Patients are most often white, male, and elderly. A subset of patients presents with multifocal disease and/or positive regional nodes. Although the optimal treatment is surgery followed by wide-field radiotherapy (RT), the disease is frequently so extensive at diagnosis that it is not completely resectable. Even after optimal local-regional treatment, there is a relatively high likelihood of a local recurrence at the margins of the RT fields. The probability of hematogenous dissemination is relatively high. Limited data suggest that chemotherapy may be useful for palliation with progression-free survival rates ranging from 1 to 5 months. The 5-year local-regional control rates are approximately 40% to 50%, the 5-year distant metastasis-free survival rates range from 20% to 40%, and the 5-year survival rates range from 10% to 30%.
Cutaneous angiosarcoma is a rare, aggressive malignancy that is optimally treated with resection and wide-field postoperative RT. The likelihood of local-regional failure is high, as is the risk of distant relapse. Chemotherapy may be useful for short-term palliation.
探讨皮肤血管肉瘤的治疗方法及预后。
回顾相关文献。
皮肤血管肉瘤是一种罕见的侵袭性恶性肿瘤，预后较差。它通常发生于头皮或面部，就诊时多为局部晚期。患者多为白人、男性且年龄较大。一部分患者表现为多灶性病变和/或区域淋巴结阳性。尽管最佳治疗方法是手术联合大范围放疗（RT），但该疾病在诊断时往往范围广泛，无法完全切除。即使经过最佳的局部区域治疗，放疗野边缘局部复发的可能性仍相对较高。血行转移的概率相对较高。有限的数据表明，化疗可能有助于缓解症状，无进展生存期为1至5个月。5年局部区域控制率约为40%至50%，5年无远处转移生存率为20%至40%，5年生存率为10%至30%。
皮肤血管肉瘤是一种罕见的侵袭性恶性肿瘤，最佳治疗方法是手术切除并术后进行大范围放疗。局部区域失败的可能性很高，远处复发的风险也很高。化疗可能有助于短期缓解症状。
