Shaw R D
Research Service (151), Northport VA Medical Center, Northport, NY 11768, USA.
Curr Opin Gastroenterol. 1999 Jan;15(1):53-8. doi: 10.1097/00001574-199901000-00010.
Viral gastroenteritis is a major worldwide public health problem. The number of identified pathogens continues to increase, and characterization of the viral structures and functions must be inexorably pursued. Investigators have made considerable progress toward understanding the mechanisms of virus-cell interactions, host responses, and pathogenesis, but the application of this knowledge to improve disease treatment and prevention awaits further key discoveries. Despite deficiencies in knowledge of many aspects of these important issues, a vaccine for the most important pathogen, rotavirus, has been submitted to the US Food and Drug Administration for approval.
病毒性肠胃炎是一个全球性的重大公共卫生问题。已识别病原体的数量持续增加，因此必须坚持不懈地对病毒的结构和功能进行表征。研究人员在了解病毒与细胞相互作用机制、宿主反应和发病机制方面取得了相当大的进展，但将这些知识应用于改善疾病治疗和预防仍有待进一步的关键发现。尽管在这些重要问题的许多方面知识存在不足，但针对最重要的病原体轮状病毒的疫苗已提交给美国食品药品监督管理局审批。
