Schiesser Carl H
Australian Research Council Centre for Free Radical Chemistry and Biotechnology, School of Chemistry, The University of Melbourne, Victoria, Australia.
Chem Commun (Camb). 2006 Oct 21(39):4055-65. doi: 10.1039/b608150a. Epub 2006 Aug 10.
Free radical chemistry has come a long way in a relatively short period of time. Armed with mechanistic and rate constant data, the synthetic practitioner can now apply free radical chemistry to the synthesis of many different classes of target molecule with confidence. This Feature Article highlights progress made in the understanding and application of free radical reactions at main group higher heteroatoms and demonstrates how this knowledge can be used to construct interesting higher heterocycles, many of which exhibit biological activity, through the use of intramolecular homolytic substitution chemistry.
自由基化学在相对较短的时间内取得了长足的发展。有了反应机理和速率常数数据，合成从业者现在可以自信地将自由基化学应用于多种不同类型目标分子的合成。这篇专题文章重点介绍了在理解和应用主族高杂原子自由基反应方面取得的进展，并展示了如何通过分子内均裂取代化学利用这些知识构建有趣的高级杂环，其中许多杂环具有生物活性。
