Skyggedal Rasmussen Hanne Marie, Søndergaard Jens, Sokolowski Ineta, Kampmann Jens Peter, Andersen Morten
Research Unit for General Practice, Institute of Public Health, University of Southern Denmark, Odense, J.B. Winsløws Vej 9A, DK-5000, Odense, Denmark.
Eur J Clin Pharmacol. 2006 Nov;62(11):953-8. doi: 10.1007/s00228-006-0196-x. Epub 2006 Oct 6.
To test a method for improving the selection of indicators of general practitioners' prescribing.
We conducted a prescription database study including all 180 general practices in the County of Funen, Denmark, approximately 472,000 inhabitants. Principal factor analysis was used to model correlation between 19 register-based indicators for the quality of non-steroidal anti-inflammatory drug (NSAID) prescribing.
The correlation between indicators ranged widely from 0 to 0.93. Factor analysis revealed three dimensions of quality: (1) "Coxib preference", comprising indicators directly quantifying choice of coxibs, indicators measuring expenditure per Defined Daily Dose, and indicators taking risk aspects into account, (2) "Frequent NSAID prescribing", comprising indicators quantifying prevalence or amount of NSAID prescribing, and (3) "Diverse NSAID choice", comprising indicators focusing on the width of GPs' formularies. The number of indicators for measuring the important aspects of quality in prescribing of NSAIDs could be reduced substantially by selecting the indicator in each dimension with the highest factor loading. A high preference for coxibs indicated both appropriate and inappropriate prescribing, as revealed by the correlation of the indicators in the first factor.
Correlation and factor analysis is a feasible method that assists the selection of indicators and gives better insight into prescribing patterns.
测试一种改进全科医生处方指标选择的方法。
我们进行了一项处方数据库研究,涵盖丹麦菲英岛县的所有180家全科诊所,约47.2万居民。运用主成分因子分析对19项基于登记册的非甾体抗炎药(NSAID)处方质量指标之间的相关性进行建模。
指标之间的相关性范围很广,从0到0.93。因子分析揭示了质量的三个维度:(1)“昔布类偏好”,包括直接量化昔布类选择的指标、衡量每限定日剂量支出的指标以及考虑风险因素的指标;(2)“频繁开具NSAID处方”,包括量化NSAID处方患病率或数量的指标;(3)“多样的NSAID选择”,包括关注全科医生处方集广度的指标。通过选择每个维度中因子载荷最高的指标,可大幅减少用于衡量NSAID处方质量重要方面的指标数量。如第一个因子中指标的相关性所示,对昔布类的高度偏好既表明了适当的处方,也表明了不适当的处方。
相关性和因子分析是一种可行的方法,有助于指标的选择,并能更好地洞察处方模式。