Akiyama M, Iijima M, Fujisawa R
Department of Dermatology, Showa University School of Medicine.
Nihon Hifuka Gakkai Zasshi. 1990 Sep;100(10):1057-60.
We reported 7 cases of drug eruption due to Iohexol (Omnipaque) which was nonionic X-ray contrast agent without severe adverse reaction. They showed generalized edematous and erythematous plaques. The eruption appeared from 5 to 6 days after the examination when a patient had not been sensitized, or several hours after that when he/she had been already sensitized. No case showed any cross-sensitization with ionic contrast media, but some cases suggested the possibility of cross-sensitization among the nonionic contrast agents.
我们报告了7例因碘海醇（欧乃派克）引起的药疹，碘海醇是一种非离子型X线造影剂，未出现严重不良反应。患者表现为全身性水肿性红斑斑块。在未致敏患者中，药疹出现在检查后5至6天；而在已致敏患者中，药疹出现在检查后数小时。无一例患者对离子型造影剂有交叉致敏反应，但部分病例提示非离子型造影剂之间可能存在交叉致敏。
