Huang Kun, Huang Zhi-Zhen, Li Xin-Liang
School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, P. R. China.
J Org Chem. 2006 Oct 13;71(21):8320-3. doi: 10.1021/jo061507g.
As the first example for the synthesis of optically active alpha-hydroxyaldehydes and alpha-hydroxyketones in ionic liquids, we applied RTILs into L-proline catalyzed direct enantioselective alpha-aminoxylation of both aldehydes and ketones successfully. This protocol features a number of advantages, such as recycling of green solvents and chiral organocatalyst, high yields, excellent enantioselectivities, short reaction times, and broad substrate scope.
作为在离子液体中合成光学活性α-羟基醛和α-羟基酮的首个实例，我们成功地将室温离子液体应用于L-脯氨酸催化的醛和酮的直接对映选择性α-氨氧基化反应。该方法具有诸多优点，如绿色溶剂和手性有机催化剂的循环利用、高收率、优异的对映选择性、短反应时间以及广泛的底物范围。
