α-取代丙二酸酯的有机催化不对称亚硝基醛醇反应。
Organocatalytic asymmetric nitroso aldol reaction of αsubstituted malonamates.
作者信息
Gupta Ekta, Vaishanv Narendra Kumar, Kumar Sandeep, Purshottam Raja Krishnan, Kant Ruchir, Mohanan Kishor
机构信息
Medicinal & Process Chemistry Division, CSIR-Central Drug Research Institute, BS-10/1, Sector 10, Jankipuram extension, Sitapur Road, P.O. Box 173, Lucknow 226031, India.
Sophisticated Analytical Instrument Facility CSIR-Central Drug Research Institute, BS-10/1, Sector 10, Jankipuram extension, Sitapur Road, P.O. Box 173, Lucknow 226031, India.
出版信息
Beilstein J Org Chem. 2022 Feb 21;18:217-224. doi: 10.3762/bjoc.18.25. eCollection 2022.
A practical enantioselective N-selective nitroso aldol reaction of α-methylmalonamates with a nitrosoarene is reported. The reaction employs the Takemoto thiourea catalyst for the induction of enantioselectivity, and the corresponding optically active oxyaminated malonamates were obtained in reasonably good yields.
报道了一种α-甲基丙二酸酯与亚硝基芳烃的实用对映选择性N-选择性亚硝基羟醛缩合反应。该反应采用武田硫脲催化剂诱导对映选择性，并以相当好的产率得到了相应的光学活性氧化氨基丙二酸酯。
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