Maione T E, Sharpe R J
Repligen Corporation, Cambridge, MA 02139.
Trends Pharmacol Sci. 1990 Nov;11(11):457-61. doi: 10.1016/0165-6147(90)90127-t.
Angiogenesis, the development of new blood vessels, is associated with many life-threatening pathologies. The neovascularization of tumors for example, allows a blood supply to deliver the required nutrients for tumor development. Inappropriate blood vessel growth also contributes to the pathology of other diseases such as atherosclerosis and arthritis. The process of angiogenesis is beginning to be better understood, and as Ted Maione and Richard Sharpe explain, this understanding has led to the identification of several lead compounds that inhibit this process. At present all of these candidate drugs exhibit severe host toxicity, but more selective angiogenesis inhibitors might be expected to be extremely useful therapeutic agents.
血管生成，即新血管的形成，与许多危及生命的病理状况相关。例如，肿瘤的新血管化使得血液供应能够为肿瘤生长提供所需营养。不适当的血管生长也会导致其他疾病如动脉粥样硬化和关节炎的病理过程。血管生成的过程正逐渐被更好地理解，正如泰德·马奥尼和理查德·夏普所解释的，这种理解已促使人们鉴定出几种抑制该过程的先导化合物。目前，所有这些候选药物都表现出严重的宿主毒性，但预计更具选择性的血管生成抑制剂可能会成为极为有用的治疗药物。
