Verleden G M, Belvisi M G, Stretton C D, Barnes P J
Department of Thoracic Medicine, National Heart and Lung Institute, London, United Kingdom.
Am Rev Respir Dis. 1991 Jan;143(1):114-8. doi: 10.1164/ajrccm/143.1.114.
Nonadrenergic, noncholinergic (NANC) neural bronchoconstrictor responses in guinea pig airways are due to the release of tachykinins from sensory nerves. We have performed an in vitro study using electrical field stimulation (EFS; 40 V, 0.5 ms, 8 Hz for 20 s) in guinea pig bronchi to investigate the effect of nedocromil sodium (NS) on NANC bronchoconstrictor responses. NS inhibited NANC bronchoconstriction in bronchi in a concentration-dependent manner, with a maximum inhibition of 40 +/- 4% (p less than 0.001, n = 6) at 100 microM. Cromolyn sodium, however, produced only 9 +/- 8% inhibition at the same molar concentration (p less than 0.05). NS did not affect the contractile response to substance P, nor did it modulate the cholinergic bronchoconstrictor response to EFS in tracheal smooth muscle. These results indicate that NS may modulate the release of tachykinins from airway sensory nerves.
豚鼠气道中的非肾上腺素能、非胆碱能（NANC）神经支气管收缩反应是由于感觉神经释放速激肽所致。我们进行了一项体外研究，在豚鼠支气管中使用电场刺激（EFS；40V，0.5ms，8Hz，持续20s）来研究奈多罗米钠（NS）对NANC支气管收缩反应的影响。NS以浓度依赖的方式抑制支气管中的NANC支气管收缩，在100μM时最大抑制率为40±4%（p<0.001，n = 6）。然而，在相同摩尔浓度下，色甘酸钠仅产生9±8%的抑制作用（p<0.05）。NS不影响对P物质的收缩反应，也不调节气管平滑肌中对EFS的胆碱能支气管收缩反应。这些结果表明，NS可能调节气道感觉神经中速激肽的释放。
