Korn C, Schwarz U S
University of Heidelberg, Im Neuenheimer Feld 293, D-69120 Heidelberg, Germany.
Phys Rev Lett. 2006 Sep 29;97(13):138103. doi: 10.1103/PhysRevLett.97.138103. Epub 2006 Sep 28.
We theoretically investigate the efficiency of initial binding between a receptor-coated sphere and a ligand-coated wall in linear shear flow. The mean first passage time for binding decreases monotonically with increasing shear rate. Above a saturation threshold of the order of a few 100 receptor patches, the binding efficiency is enhanced only weakly by increasing their number and size, but strongly by increasing their height. This explains why white blood cells in the blood flow adhere through receptor patches localized to the tips of microvilli, and why malaria-infected red blood cells form elevated receptor patches (knobs).
我们从理论上研究了在直线剪切流中，受体包被的球体与配体包被的壁之间初始结合的效率。结合的平均首次通过时间随剪切速率的增加而单调减少。在几百个受体斑块数量级的饱和阈值之上，增加受体斑块的数量和大小对结合效率的增强作用较弱，但增加其高度则有显著增强作用。这解释了为什么血流中的白细胞通过定位于微绒毛尖端的受体斑块实现黏附，以及为什么感染疟疾的红细胞会形成升高的受体斑块（凸起）。
