Correia Marcelo L G, Rahmouni Kamal
Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA.
Diabetes Obes Metab. 2006 Nov;8(6):603-10. doi: 10.1111/j.1463-1326.2005.00562.x.
To review the potential role of leptin, hyperleptinaemia and leptin resistance in the cardiovascular and endocrine complications of metabolic syndrome.
Review of literature listed in Medline.
Hyperleptinaemia is common in obesity and reflects increased adiposity and leptin resistance. Nevertheless, leptin resistance may not be complete as several actions of leptin, such as cardiovascular sympatho-activation, might be preserved in obese subjects known to be resistant to the metabolic effects of leptin (i.e. selective leptin resistance). Notably, the renal and sympathetic actions of leptin may play an important role in the pathogenesis of hypertension related to obesity and metabolic syndrome. Furthermore, the lipotoxic effect of leptin resistance may cause insulin resistance and beta cell dysfunction, increasing the risk of type 2 diabetes. Leptin has also been shown to possess proliferative, pro-inflammatory, pro-thrombotic, and pro-oxidative actions.
Hyperleptinaemia and leptin resistance may contribute to hypertension, impaired glucose metabolism, and pro-atherogenic state in obesity and metabolic syndrome.
综述瘦素、高瘦素血症及瘦素抵抗在代谢综合征的心血管和内分泌并发症中的潜在作用。
回顾Medline中列出的文献。
高瘦素血症在肥胖症中常见，反映了肥胖程度增加及瘦素抵抗。然而，瘦素抵抗可能并不完全，因为瘦素的一些作用，如心血管交感神经激活，在已知对瘦素代谢作用有抵抗的肥胖受试者（即选择性瘦素抵抗）中可能得以保留。值得注意的是，瘦素的肾脏和交感神经作用可能在与肥胖和代谢综合征相关的高血压发病机制中起重要作用。此外，瘦素抵抗的脂毒性作用可能导致胰岛素抵抗和β细胞功能障碍，增加2型糖尿病的风险。瘦素还被证明具有增殖、促炎、促血栓形成和促氧化作用。
高瘦素血症和瘦素抵抗可能导致肥胖症和代谢综合征中的高血压、糖代谢受损及动脉粥样硬化前期状态。
