Natural inhibitors targeting osteoclast-mediated bone resorption.
作者信息
Zeng Guang-Zhi, Tan Ning-Hua, Hao Xiao-Jiang, Mu Quan-Zhang, Li Rong-Tao
机构信息
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, China; Graduate School of the Chinese Academy of Sciences, Beijing 100039, China.
出版信息
Bioorg Med Chem Lett. 2006 Dec 15;16(24):6178-80. doi: 10.1016/j.bmcl.2006.09.042. Epub 2006 Oct 5.
Human cathepsin K, matrix metalloproteinase 9, and alpha(V)beta(3) integrin are the key regulators in osteoclast-mediated bone resorption. In this paper, we found natural inhibitors 1-10 for them by enzyme inhibition assays. Inhibitors 1-7, 8-9, and 10 are novel inhibitors of human cathepsin K, matrix metalloproteinase 9, and alpha(V)beta(3), respectively.
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