Thomas-Anterion C, Laurent B
Unité de Neuropsychologie, CM2R, CHU Bellevue, 42055 Saint-Etienne cedex 05, France.
Rev Neurol (Paris). 2006 Oct;162(10):913-20. doi: 10.1016/s0035-3787(06)75100-1.
Better knowledge of the preclinical phase of Alzheimer's disease and of the symptomatic pre-dementia stage designated "mild cognitive impairment" will require considerable progress in our understanding of neuropsychological processes. The results of studies suggest that impaired performance in memory tests may serve as a marker for Alzheimer's disease. The best current predictors include stringent tests of episodic memory and recognition tests. The early stages of Alzheimer's disease also seem to involve subtle deficits in semantic memory and attentional processes. Face recognition and denomination seem to be useful tools. Greater accuracy and precision in the transitional zone between healthy aging and the first manifestations of Alzheimer's disease will require work combining data on neuropsychological profiles and neuroimaging.
要更好地了解阿尔茨海默病的临床前期以及被称为“轻度认知障碍”的症状性痴呆前阶段,我们需要在理解神经心理过程方面取得相当大的进展。研究结果表明,记忆测试中的表现受损可能是阿尔茨海默病的一个标志。目前最好的预测指标包括对情景记忆的严格测试和识别测试。阿尔茨海默病的早期阶段似乎还涉及语义记忆和注意力过程的细微缺陷。人脸识别和命名似乎是有用的工具。要在健康衰老与阿尔茨海默病最初表现之间的过渡阶段提高准确性和精确性,需要将神经心理特征数据与神经影像学数据结合起来进行研究。