Xu Chen, Gong Jun-Fang, Yue Su-Fang, Zhu Yu, Wu Yang-Jie
Department of Chemistry, Henan Key Laboratory of Chemical Biology and Organic Chemistry, Key Laboratory of Applied Chemistry of Henan Universities, Zhengzhou University, Zhengzhou, 450052, P R China.
Dalton Trans. 2006 Oct 21(39):4730-9. doi: 10.1039/b608825b. Epub 2006 Aug 9.
A series of novel tricyclohexylphosphine (PCy(3))-cyclopalladated ferrocenylimine complexes 2c-2g have been easily synthesized. These new palladacycles are thermally stable and are not sensitive to air and moisture. Their detailed structures have been determined by single-crystal X-ray analysis and six different types of intermolecular hydrogen bonds are found to be existed in the crystals of these complexes. The use of 2c-2g as catalysts for Suzuki and Heck reactions was examined. They were found to be very efficient for the Suzuki reaction of aryl chlorides with phenylboronic acid. Typically, using 0.1 mol% of catalyst in the presence of 1.5 equivalent of Cs(2)CO(3) as base in dioxane at 100 degrees C provided coupled products in excellent yields. These complexes also displayed good activity in the Heck reaction of a range of aryl bromides with acrylic acid ethyl ester although they were not particularly useful for the activation of aryl chlorides.
一系列新型的三环己基膦（PCy₃）-环钯化二茂铁基亚胺配合物2c - 2g已被轻松合成。这些新的钯环配合物热稳定性良好，对空气和湿气不敏感。它们的详细结构已通过单晶X射线分析确定，并且在这些配合物的晶体中发现存在六种不同类型的分子间氢键。考察了2c - 2g作为铃木反应和赫克反应催化剂的用途。发现它们对于芳基氯与苯硼酸的铃木反应非常有效。通常，在100℃下于二氧六环中，使用0.1 mol%的催化剂并以1.5当量的碳酸铯作为碱，能以优异的产率得到偶联产物。这些配合物在一系列芳基溴与丙烯酸乙酯的赫克反应中也表现出良好的活性，尽管它们对芳基氯的活化并非特别有效。
