Asakawa Junichi, Kobayashi Shigeto, Kaneda Kazuhiko, Ogasawara Hitoshi, Sugawara Masahiro, Yasuda Masahiko, Hashimoto Hiroshi
Department of Rheumatology, School of Medicine, Juntendo University, Tokyo, Japan.
Mod Rheumatol. 2005;15(4):283-5. doi: 10.1007/s10165-005-0399-5.
We describe a patient with reactive arthritis (ReA) induced by influenza vaccination. A healthy 79-year-old Japanese man began suffering from migrating polyarthritis 2 days after receiving influenza vaccine. He proved negative for rheumatoid factor, showing no evidence for microbial infections such as Streptoccocci, Chlamydia, or Parbovirus B19. Human leukocyte antigen (HLA) typing analysis revealed positive results for HLA-B54 (22), which is one of the cross-reactive antigens to HLA-B27. His arthritis improved with administration of nonsteroidal anti-inflammatory drugs, and recovery was attained within 6 weeks. Reactive arthritis is a rare adverse effect induced by influenza vaccination; however, it is important that it is recognized by all physicians.
我们描述了一名因流感疫苗接种诱发反应性关节炎（ReA）的患者。一名79岁健康的日本男性在接种流感疫苗2天后开始出现游走性多关节炎。他的类风湿因子检测呈阴性，未发现诸如链球菌、衣原体或细小病毒B19等微生物感染的证据。人类白细胞抗原（HLA）分型分析显示HLA - B54（22）呈阳性，HLA - B54是与HLA - B27交叉反应的抗原之一。给予非甾体抗炎药后他的关节炎有所改善，并在6周内康复。反应性关节炎是流感疫苗接种诱发的罕见不良反应；然而，所有医生都认识到这一点很重要。
