FK506与环孢素对人体外天然及抗体依赖性细胞毒性反应的影响。
Effect of FK506 versus cyclosporine on human natural and antibody-dependent cytotoxicity reactions in vitro.
作者信息
Wasik M, Gorski A, Stepien-Sopniewska B, Lagodzinski Z
机构信息
Department of Immunology, Warsaw Medical School, Poland.
出版信息
Transplantation. 1991 Jan;51(1):268-70. doi: 10.1097/00007890-199101000-00045.
Abstract
The effect of FK506 and cyclosporine on NK and ADCC activity was evaluated. Cytotoxic cells mediating both activities are resistant to FK506. In contrast, preincubation of ADCC and NK effectors with cyclosporine decreases their cytotoxic potential, while adding the drug to the assays is without effect.
摘要
评估了FK506和环孢素对自然杀伤细胞（NK）活性及抗体依赖的细胞介导的细胞毒性作用（ADCC）的影响。介导这两种活性的细胞毒性细胞对FK506具有抗性。相比之下，用环孢素对ADCC和NK效应细胞进行预孵育会降低它们的细胞毒性潜能，而在检测中加入该药物则没有作用。
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