血小板糖蛋白GPIbα Kozak基因多态性与短暂性脑缺血发作的相关性
[Correlation between the polymorphism of platelet glycoprotein GPIb α Kozak gene and transient ischemic attack].
作者信息
Song Yu-qiang, Zou Hong-li, Zhang Chen
机构信息
Department of Neurology,the Affiliated Hospital of Medical College, Qingdao University, Qingdao, Shangdong, 266003 PR China.
出版信息
Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2006 Oct;23(5):561-4.
OBJECTIVE
Genic susceptibility could increase the risk of transient ischemic attack (TIA). The objective of this study is to investigate the relationship between the polymorphism of platelet glycoprotein GPIb α Kozak gene and TIA in Qindao Han population.
METHODS
The polymorphisms of platelet glycoprotein GPIb α Kozak gene -5T/C in TIA patients and normal control were detected with sequence-specific primers polymerase chain reaction (PCR-SSP).
RESULTS
The prevalence of the CC genotype and C alleles were significantly higher in TIA patients than in the control group (P<0.05). The positive correlation between C allele and TIA was showed by logistic regression analysis (P=0.016).
CONCLUSION
The -5T/C polymorphism of the platelet glycoprotein GPIb α Kozak gene is implicated in the pathogenesis of TIA. C allele is an independent risk factor for TIA.
目的
基因易感性可能会增加短暂性脑缺血发作（TIA）的风险。本研究的目的是探讨青岛汉族人群中血小板糖蛋白GPIbα Kozak基因多态性与TIA之间的关系。
方法
采用序列特异性引物聚合酶链反应（PCR-SSP）检测TIA患者和正常对照者血小板糖蛋白GPIbα Kozak基因-5T/C的多态性。
结果
TIA患者中CC基因型和C等位基因的发生率显著高于对照组（P<0.05）。Logistic回归分析显示C等位基因与TIA呈正相关（P=0.016）。
结论
血小板糖蛋白GPIbα Kozak基因的-5T/C多态性与TIA的发病机制有关。C等位基因是TIA的独立危险因素。
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