血清素转运体启动子多态性与具有高医学损害的自杀未遂者的关联。
Association of the serotonin transporter promotor polymorphism with suicide attempters with a high medical damage.
作者信息
Wasserman Danuta, Geijer Thomas, Sokolowski Marcus, Frisch Amos, Michaelovsky Elena, Weizman Abraham, Rozanov Vsevolod, Wasserman Jerzy
机构信息
The National and the Stockholm County Centre for Suicide Research and Prevention of Mental Ill-Health, Dep of the Public Health Sciences, Karolinska Institute, Stockholm, Sweden.
出版信息
Eur Neuropsychopharmacol. 2007 Feb;17(3):230-3. doi: 10.1016/j.euroneuro.2006.08.006. Epub 2006 Oct 9.
Serotonergic neurotransmission has been implicated in suicidal behavior, including inconsistent results concerning the serotonin transporter promoter polymorphism (5-HTTLPR). Here, we analyzed the 5-HTTLPR in suicide attempters (n=85). Comparing the presence of SS with SL+LL genotypes showed a significantly higher prevalence of the SS genotype in suicide attempters with high medical damage scores (chi2=9.054, df=1, p=0.0026). The results suggest that the S-allele may predispose for suicidal behavior characterized by high determination.
血清素能神经传递与自杀行为有关，包括血清素转运体启动子多态性（5-HTTLPR）方面的结果不一致。在此，我们分析了自杀未遂者（n = 85）的5-HTTLPR。比较SS与SL + LL基因型的存在情况，发现在具有高医疗损伤评分的自杀未遂者中，SS基因型的患病率显著更高（χ2 = 9.054，自由度 = 1，p = 0.0026）。结果表明，S等位基因可能易导致以高决心为特征的自杀行为。
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