二十碳五烯酸补充剂对大鼠卵巢切除术后骨骼的有害影响。

Detrimental effect of eicosapentaenoic acid supplementation on bone following ovariectomy in rats.

作者信息

Poulsen Raewyn C, Kruger Marlena C

机构信息

Institute of Food Nutrition and Human Health, Massey University, Palmerston North, New Zealand.

出版信息

Prostaglandins Leukot Essent Fatty Acids. 2006 Dec;75(6):419-27. doi: 10.1016/j.plefa.2006.08.003. Epub 2006 Oct 9.

DOI:10.1016/j.plefa.2006.08.003

PMID:17029936

Abstract

Although several studies have reported a positive effect of n-3 essential fatty acids (EFAs) on bone density post-ovariectomy, the role of specific EFAs has yet to be fully elucidated. In this study, ovariectomised (OVX) rats were supplemented with 0.1 g (LOW) or 1.0 g (HIGH) of eicosapentaenoic acid (EPA)/kg body weight for 9 weeks. Bone mineral density (BMD), 25-hydroxyvitamin D(3) and plasma fatty acid profile were compared to those of OVX and sham animals fed a non-supplemented diet. BMD decreased significantly in all OVX (P<0.001) but not sham rats. There was no difference in BMD between the LOW group and OVX controls. BMD was significantly lower in the HIGH group compared to OVX and sham controls. 25-hydroxyvitamin D(3) levels were significantly higher in both the LOW and HIGH groups compared to OVX controls (P=0.0006 and 0.02, respectively). In conclusion, high-dose EPA supplementation exacerbated the effects of ovariectomy on BMD.

摘要

尽管多项研究报告了n-3必需脂肪酸（EFA）对卵巢切除术后骨密度有积极影响，但特定EFA的作用尚未完全阐明。在本研究中，给去卵巢（OVX）大鼠补充0.1 g（低剂量组）或1.0 g（高剂量组）/千克体重的二十碳五烯酸（EPA），持续9周。将骨矿物质密度（BMD）、25-羟基维生素D(3)和血浆脂肪酸谱与未补充饮食的OVX大鼠和假手术动物进行比较。所有OVX大鼠的BMD均显著降低（P<0.001），但假手术大鼠未出现这种情况。低剂量组与OVX对照组之间的BMD没有差异。与OVX对照组和假手术对照组相比，高剂量组的BMD显著更低。与OVX对照组相比，低剂量组和高剂量组的25-羟基维生素D(3)水平均显著更高（分别为P=0.0006和0.02）。总之，高剂量补充EPA会加剧卵巢切除术对BMD的影响。