Elomaa Annika, Advani Abdolreza, Donnelly Declan, Antila Mia, Mertsola Jussi, He Qiushui, Hallander Hans
Pertussis Reference Laboratory, National Public Health Institute, Turku, Finland.
Vaccine. 2007 Jan 15;25(5):918-26. doi: 10.1016/j.vaccine.2006.09.012. Epub 2006 Sep 20.
Pertussis is an infectious disease of the respiratory tract in humans caused by Bordetella pertussis. Despite extensive vaccinations, pertussis has remained endemic and re-emerged. In Finland, a whole-cell pertussis vaccine has been used since 1952 with high coverage. In Sweden, whole-cell vaccinations were introduced in 1953 but ceased in 1979, and pertussis vaccinations with acellular vaccines were introduced in 1996. Two epidemic peaks occurred in Sweden in 1999 and 2002 and in Finland in 1999 and 2003. We compared Finnish (N=193) and Swedish (N=455) B. pertussis isolates circulating in 1998-2003 together with vaccine strains used in these neighbouring countries with different vaccination histories. The isolates were analysed by serotyping, genotyping of pertussis toxin S1 subunit and pertactin, and pulsed-field gel electrophoresis. The results suggest that the sequential epidemics were caused by clonal expansion of a certain B. pertussis strain possibly transmitted from Sweden to Finland. The roles of antigenic variation in immunity-driven evolution of B. pertussis in both countries are discussed.
百日咳是由百日咳博德特氏菌引起的人类呼吸道传染病。尽管进行了广泛的疫苗接种，但百日咳仍呈地方性流行且再度出现。在芬兰，自1952年以来一直使用全细胞百日咳疫苗，接种率很高。在瑞典，1953年引入全细胞疫苗接种，但在1979年停止，1996年引入无细胞疫苗进行百日咳疫苗接种。瑞典在1999年和2002年以及芬兰在1999年和2003年出现了两个流行高峰。我们将1998 - 2003年期间在芬兰（N = 193）和瑞典（N = 455）流行的百日咳博德特氏菌分离株与这些邻国使用的具有不同疫苗接种历史的疫苗株进行了比较。通过血清分型、百日咳毒素S1亚基和百日咳黏附素的基因分型以及脉冲场凝胶电泳对分离株进行了分析。结果表明，连续的疫情是由某种百日咳博德特氏菌菌株的克隆扩增引起的，该菌株可能从瑞典传播到了芬兰。讨论了抗原变异在两国百日咳博德特氏菌免疫驱动进化中的作用。
