贝伐单抗/氟尿嘧啶、亚叶酸钙、伊立替康方案治疗转移性结肠癌后出现的可逆性后部白质脑病综合征
Reversible posterior leukoencephalopathy syndrome after bevacizumab/FOLFIRI regimen for metastatic colon cancer.
作者信息
Allen Jeffrey A, Adlakha Ashish, Bergethon Peter R
机构信息
Department of Neurology, Tufts -- New England Medical Center, Boston, Mass, USA.
出版信息
Arch Neurol. 2006 Oct;63(10):1475-8. doi: 10.1001/archneur.63.10.1475.
OBJECTIVE
To describe a patient with reversible posterior leukoencephalopathy syndrome following the administration of bevacizumab (Avastin), a monoclonal antibody against vascular endothelial growth factor.
DESIGN
Case report/literature review.
SETTING
University hospital.
PATIENT
A 52-year-old man receiving chemotherapy for stage IV rectal carcinoma.
RESULTS
Clinical and radiographic evidence consistent with reversible posterior leukoencephalopathy syndrome was found following the administration of irinotecan hydrochloride, leucovorin calcium, and fluorouracil (FOLFIRI) regimen chemotherapy and bevacizumab.
CONCLUSIONS
Reversible posterior leukoencephalopathy syndrome following treatment with angiogenesis modulators can occur. In addition to raising clinical suspicion in appropriate patients, this report may yield clues to the pathophysiologic underpinnings of reversible posterior leukoencephalopathy syndrome.
目的
描述一名在使用贝伐单抗（阿瓦斯汀）（一种抗血管内皮生长因子的单克隆抗体）后出现可逆性后部白质脑病综合征的患者。
设计
病例报告/文献综述。
地点
大学医院。
患者
一名52岁男性，因IV期直肠癌接受化疗。
结果
在给予盐酸伊立替康、亚叶酸钙和氟尿嘧啶（FOLFIRI）方案化疗及贝伐单抗后，发现了与可逆性后部白质脑病综合征相符的临床和影像学证据。
结论
使用血管生成调节剂治疗后可能发生可逆性后部白质脑病综合征。除了提高对合适患者的临床怀疑外，本报告可能为可逆性后部白质脑病综合征的病理生理基础提供线索。
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