草药提取物对链脲佐菌素诱导的糖尿病大鼠的降血糖活性。
Antihyperglycemic activity of herb extracts on streptozotocin-induced diabetic rats.
作者信息
Jung Chang Hwa, Zhou Song, Ding Guo Xun, Kim Ji Hye, Hong Myung Hee, Shin Yong-Cheol, Kim Gyung Jun, Ko Seong-Gyu
机构信息
Laboratory of Clinical Biology and Pharmacogenomics, College of Oriental Medicine, Kyunghee University, South Korea.
出版信息
Biosci Biotechnol Biochem. 2006 Oct;70(10):2556-9. doi: 10.1271/bbb.60238. Epub 2006 Oct 7.
We investigated the effects of herb extracts, Rhus verniciflua, Agrimonia pilosa, Sophora japonica, and Paeonia suffruticosa, on the lowering of blood glucose levels and thiobarbituric acid reactive substances (TBARS) in streptozotocin (STZ)-induced diabetic rats. After 4 weeks, oral administration of Rhus verniciflua extract (50 mg/kg) exhibited a significant decrease in blood glucose levels in diabetic rats (P<0.05). Blood TBARS concentrations, the products of glucose oxidation in blood, were also lowered by Rhus verniciflua extract supplementation. In addition, Sophora japonica and Paeonia suffruticosa extracts significantly reduced TBARS levels versus diabetic controls. Serum concentrations of liver-function marker enzymes, GOT and GPT, were also restored by Rhus verniciflua (50 mg/kg) supplementation in diabetic rats.
我们研究了漆树、仙鹤草、槐米和牡丹皮等草药提取物对链脲佐菌素（STZ）诱导的糖尿病大鼠血糖水平降低及硫代巴比妥酸反应性物质（TBARS）的影响。4周后，口服漆树提取物（50毫克/千克）可使糖尿病大鼠的血糖水平显著降低（P<0.05）。血液中TBARS浓度（血液中葡萄糖氧化的产物）也因补充漆树提取物而降低。此外，与糖尿病对照组相比，槐米和牡丹皮提取物显著降低了TBARS水平。补充漆树提取物（50毫克/千克）还使糖尿病大鼠血清中肝功能标志物酶谷草转氨酶（GOT）和谷丙转氨酶（GPT）的浓度恢复正常。
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