转化生长因子β介导的信号传导及转录调控在胰腺发育和癌症中的作用
TGFbeta-mediated signaling and transcriptional regulation in pancreatic development and cancer.
作者信息
Ellenrieder V, Fernandez Zapico M E, Urrutia R
机构信息
Mayo Clinic, Rochester, Minnesota, USA.
出版信息
Curr Opin Gastroenterol. 2001 Sep;17(5):434-40. doi: 10.1097/00001574-200109000-00006.
Transforming growth factor-beta (TGFbeta) plays a critical role in pancreatic development and cell proliferation. Binding of TGFbeta to its membrane receptor kinases activates the Smad signaling proteins, allowing them to translocate to the nucleus and participate in the transcriptional control of TGFbeta target genes. In addition, there is an increasing number of cellular mechanisms affecting the final response of a cell to TGFbeta. This includes crosstalk with other signaling pathways and the induction of TGFbeta early response genes, such as the TGFbeta-inducible early response gene (TIEG) family of transcription factors. Like the Smads, TIEGs behave as downstream effector proteins in TGFbeta-mediated pancreatic growth control. The discovery of the Smads and TIEGs has provided new insights into TGFbeta-regulated functions. Their significance in pancreatic development and cancer is discussed in this review.
转化生长因子-β（TGFβ）在胰腺发育和细胞增殖中起着关键作用。TGFβ与其膜受体激酶结合会激活Smad信号蛋白，使其能够转运至细胞核并参与TGFβ靶基因的转录调控。此外，影响细胞对TGFβ最终反应的细胞机制数量也在不断增加。这包括与其他信号通路的相互作用以及TGFβ早期反应基因的诱导，如TGFβ诱导早期反应基因（TIEG）转录因子家族。与Smads一样，TIEGs在TGFβ介导的胰腺生长控制中作为下游效应蛋白发挥作用。Smads和TIEGs的发现为TGFβ调节的功能提供了新的见解。本综述讨论了它们在胰腺发育和癌症中的意义。
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