• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

TGFbeta signaling in growth control, cancer, and heritable disorders.

作者信息

Massagué J, Blain S W, Lo R S

机构信息

Cell Biology Program, Howard Hughes Medical Institute, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA.

出版信息

Cell. 2000 Oct 13;103(2):295-309. doi: 10.1016/s0092-8674(00)00121-5.

DOI:10.1016/s0092-8674(00)00121-5
PMID:11057902
Abstract
摘要

相似文献

1
TGFbeta signaling in growth control, cancer, and heritable disorders.转化生长因子β信号传导在生长调控、癌症及遗传性疾病中的作用
Cell. 2000 Oct 13;103(2):295-309. doi: 10.1016/s0092-8674(00)00121-5.
2
TGF-beta signal transduction.转化生长因子-β信号转导
Annu Rev Biochem. 1998;67:753-91. doi: 10.1146/annurev.biochem.67.1.753.
3
[Record no. 38: TGFBR2 (type II TGFbeta receptor)].
Bull Cancer. 2000 Oct;87(10):689-90.
4
Escaping from the TGFbeta anti-proliferative control.逃脱转化生长因子β的抗增殖控制。
Carcinogenesis. 2006 Nov;27(11):2148-56. doi: 10.1093/carcin/bgl068. Epub 2006 May 12.
5
[TGF-beta signaling and carcinogenesis].[转化生长因子-β信号传导与致癌作用]
Nihon Rinsho. 2005 Apr;63 Suppl 4:549-54.
6
[Transcriptional regulation by the transforming growth factor-beta signaling].[转化生长因子-β信号通路的转录调控]
Tanpakushitsu Kakusan Koso. 2003 Dec;48(16):2247-53.
7
Selective inhibitors of type I receptor kinase block cellular transforming growth factor-beta signaling.I型受体激酶的选择性抑制剂可阻断细胞转化生长因子-β信号传导。
Biochem Pharmacol. 2004 Jul 1;68(1):41-50. doi: 10.1016/j.bcp.2004.03.011.
8
Genomic profiling identifies alterations in TGFbeta signaling through loss of TGFbeta receptor expression in human renal cell carcinogenesis and progression.基因组分析通过人肾细胞癌发生和进展过程中转化生长因子β（TGFβ）受体表达缺失，鉴定出TGFβ信号通路的改变。
Oncogene. 2003 Sep 11;22(39):8053-62. doi: 10.1038/sj.onc.1206835.
9
Interleukin 1 β-induced SMAD2/3 linker modifications are TAK1 dependent and delay TGFβ signaling in primary human mesenchymal stem cells.白细胞介素 1β诱导的 SMAD2/3 连接子修饰依赖于 TAK1，并延迟原代人骨髓间充质干细胞中的 TGFβ 信号转导。
Cell Signal. 2017 Dec;40:190-199. doi: 10.1016/j.cellsig.2017.09.010. Epub 2017 Sep 21.
10
[TGF-beta].[转化生长因子-β]
Nihon Rinsho. 2004 Feb;62 Suppl 2:73-6.

引用本文的文献

1
Network motifs and hypermotifs in TGFβ-induced epithelial to mesenchymal transition and metastasis.转化生长因子β诱导上皮-间质转化和转移中的网络基序与超级基序
Front Syst Biol. 2023 Mar 3;3:1099951. doi: 10.3389/fsysb.2023.1099951. eCollection 2023.
2
Characterization and Expression of TGF-β Proteins and Receptor in Sea Cucumber (): Insights into Potential Applications via Molecular Docking Predictions.海参中转化生长因子-β蛋白及受体的表征与表达：通过分子对接预测洞察潜在应用
Int J Mol Sci. 2025 Jul 21;26(14):6998. doi: 10.3390/ijms26146998.
3
Signalling pathways in a nutshell: from pathogenesis to therapeutical implications in prostate cancer.
简而言之：前列腺癌中的信号通路——从发病机制到治疗意义
Ann Med. 2025 Dec;57(1):2474175. doi: 10.1080/07853890.2025.2474175. Epub 2025 May 15.
4
Preclinical validation of TGFβ inhibitors as a novel therapeutic strategy for post-traumatic heterotopic ossification.转化生长因子β（TGFβ）抑制剂作为创伤后异位骨化新治疗策略的临床前验证
Sci Rep. 2025 Apr 24;15(1):14277. doi: 10.1038/s41598-025-96961-0.
5
Beyond Repetition: The Role of Gray Zone Alleles in the Upregulation of -Binding miR-323a-3p and the Modification of BMP/SMAD-Pathway Gene Expression in Human Granulosa Cells.超越重复：灰色地带等位基因在人颗粒细胞中上调与结合的miR-323a-3p及修饰BMP/SMAD信号通路基因表达中的作用
Int J Mol Sci. 2025 Mar 29;26(7):3192. doi: 10.3390/ijms26073192.
6
Dichotomous roles of ACBD3 in NSCLC growth and metastasis.ACBD3在非小细胞肺癌生长和转移中的双重作用。
Oncogene. 2025 Apr 6. doi: 10.1038/s41388-025-03360-w.
7
Transforming Growth Factor Beta2 Promotes Migration and Inhibits the Proliferation of Gastric Cancer Cells by Regulating the pSmad2/3-NDRG1 Signaling Pathway.转化生长因子β2通过调节pSmad2/3-NDRG1信号通路促进胃癌细胞迁移并抑制其增殖。
MedComm (2020). 2025 Mar 27;6(4):e70148. doi: 10.1002/mco2.70148. eCollection 2025 Apr.
8
Chaperone-mediated autophagy regulates the metastatic state of mesenchymal tumors.伴侣介导的自噬调节间充质肿瘤的转移状态。
EMBO Mol Med. 2025 Apr;17(4):747-774. doi: 10.1038/s44321-025-00210-w. Epub 2025 Mar 7.
9
Repair of Isoaspartyl Residues by PCMT1 and Kidney Fibrosis.PCMT1修复异天冬氨酰残基与肾纤维化
J Am Soc Nephrol. 2025 Mar 4;36(7):1278-94. doi: 10.1681/ASN.0000000652.
10
CD38 deficiency leads to a defective short-lived transcriptomic response to chronic graft-versus-host disease induction, involving purinergic signaling-related genes and distinct transcriptomic signatures associated with lupus.CD38缺陷导致对慢性移植物抗宿主病诱导的短期转录组反应存在缺陷，涉及嘌呤能信号相关基因以及与狼疮相关的独特转录组特征。
Front Immunol. 2025 Feb 10;16:1441981. doi: 10.3389/fimmu.2025.1441981. eCollection 2025.