Oréfice Rodrigo, Clark Arthur, West Jon, Brennan Anthony, Hench Larry
Department of Metallurgical and Materials Engineering, Federal University of Minas Gerais, R. Espírito Santo 35/206--Belo Horizonte, MG 30160-030, Brazil.
J Biomed Mater Res A. 2007 Mar 1;80(3):565-80. doi: 10.1002/jbm.a.30948.
The mismatch between the mechanical properties of bioceramics and natural tissue has restricted in several cases a wider application of ceramics in medical and dental fields. To overcome this problem, polymer matrix composites can be designed to combine bioactive properties of some bioceramics with the superior mechanical properties of some engineering plastics. In this work, polymer particulate composites composed of a high mechanical-property polymer and bioactive glass particles were produced and both the in vitro bioactivity and properties of the system were investigated. Composites with different volume fraction and particle size were prepared. In vitro tests showed that hydroxy-carbonate-apatite can be deposited on the surface of a composite as early as 20 h in a simulated body fluid. Ionic evolution from a composite with 40% volume fraction of particles was demonstrated to be similar to bulk bioactive glasses. The mechanical properties of some of the obtained composites had values comparable with the ones reported for bone. Moreover, a physical model based on dynamical mechanical tests showed evidences that the interface of the composite was aiding in the stress transfer process.
生物陶瓷与天然组织力学性能之间的不匹配在某些情况下限制了陶瓷在医学和牙科领域的更广泛应用。为克服这一问题，可设计聚合物基复合材料，将某些生物陶瓷的生物活性特性与某些工程塑料的优异力学性能结合起来。在本研究中，制备了由高力学性能聚合物和生物活性玻璃颗粒组成的聚合物颗粒复合材料，并对该体系的体外生物活性和性能进行了研究。制备了具有不同体积分数和粒径的复合材料。体外试验表明，早在模拟体液中20小时后，羟基碳酸磷灰石就能沉积在复合材料表面。含40%体积分数颗粒的复合材料的离子析出情况被证明与块状生物活性玻璃相似。所获得的一些复合材料的力学性能值与报道的骨力学性能值相当。此外，基于动态力学测试的物理模型表明，复合材料的界面有助于应力传递过程。
