Chiesa Marco, Fonagy Peter, Holmes Jeremy
The Cassel Hospital, Richmond, UK.
J Pers Disord. 2006 Oct;20(5):493-509. doi: 10.1521/pedi.2006.20.5.493.
Previous studies of long-term outcome for personality disorder (PD) were either retrospective in design or did not include a control condition. In this paper we report results for three PD cohorts (N = 111) treated in two different specialist psychosocial programs (step-down and long-term inpatient) and in general psychiatric treatment as usual (TAU), which were prospectively followed up for 72-months after intake. The three PD samples were compared on symptom severity, social adjustment, global functioning and other clinical indicators (self-mutilation, parasuicide and readmission rates) at intake, 6, 12, 24, and 72 months. Results indicated that a specialist step-down model showed significantly greater change than a purely inpatient model and TAU in most key dimensions of functioning, a difference maintained at 72-months follow-up. Improvement in the samples was not associated with amount of intercurrent treatment received in the year prior to the follow-up assessment. This study confirms that a step-down program retains significant improvement associated with a specialist psychosocial approach for PD. However, this conclusion should be qualified by design limitations. The samples were not randomly allocated to the three conditions and the naturalistic geographical allocation used in the study created a potential for a number of confounds. Whilst we used extensive statistical controls, the possibility that the differences found between the groups may be due to population differences cannot be discounted.
以往关于人格障碍(PD)长期预后的研究,要么设计上是回顾性的,要么未纳入对照条件。在本文中,我们报告了三个PD队列(N = 111)的结果,这些队列分别接受了两种不同的专科心理社会项目(逐步降级和长期住院)以及常规的普通精神科治疗(TAU),在入组后对其进行了为期72个月的前瞻性随访。对这三个PD样本在入组时、6个月、12个月、24个月和72个月时的症状严重程度、社会适应、整体功能以及其他临床指标(自我伤害、准自杀和再入院率)进行了比较。结果表明,在大多数关键功能维度上,专科逐步降级模式比单纯的住院模式和TAU显示出显著更大的变化,这种差异在72个月的随访中依然存在。样本的改善与随访评估前一年接受的并发治疗量无关。本研究证实,逐步降级项目保留了与针对PD的专科心理社会方法相关的显著改善。然而,这一结论应因设计局限性而有所保留。样本并非随机分配到这三种条件下,且研究中使用的自然地理分配方式存在一些潜在的混杂因素。虽然我们使用了广泛的统计控制,但不能排除组间发现的差异可能是由于人群差异导致的可能性。