Nakazato Y, Yamazaki H, Hirato J, Ishida Y, Yamaguchi H
Department of Pathology, Gunma University School of Medicine, Japan.
J Neuropathol Exp Neurol. 1990 Sep;49(5):521-30. doi: 10.1097/00005072-199009000-00007.
Oligodendroglial microtubular tangles (OMT), a distinctive oligodendroglial change, was observed in seven of eight cases of olivopontocerebellar atrophy (OPCA). This change was a well-defined glassy cytoplasmic structure showing intense argyrophilia. OMT were distributed in the brain stem, cerebellum, and basal ganglia where severe neurodegenerative changes were consistently observed. In 45 control cases, no OMT were found regardless of the presence or absence of neurological disorders. The OMT were immunostained by anti-tubulin antibodies, but no other antibodies reacted with them. Each OMT consisted of a meshwork of randomly oriented fibrils studded with granular and fuzzy material. The fibrillary elements were between 20 and 30 nm in diameter. It is suggested that OMT are primarily composed of altered microtubules, and are related to the neurodegenerative process of OPCA.
少突胶质细胞微管缠结（OMT）是一种独特的少突胶质细胞变化，在八例橄榄体脑桥小脑萎缩（OPCA）患者中有七例观察到这种变化。这种变化是一种界限分明的玻璃样细胞质结构，显示出强烈的嗜银性。OMT分布于脑干、小脑和基底神经节，在这些部位始终观察到严重的神经退行性变化。在45例对照病例中，无论有无神经系统疾病，均未发现OMT。OMT经抗微管蛋白抗体免疫染色，但没有其他抗体与之反应。每个OMT由随机排列的纤维网组成，纤维网上布满颗粒状和模糊物质。纤维成分的直径在20到30纳米之间。提示OMT主要由改变的微管组成，与OPCA的神经退行性过程有关。
