Johannsen Peter
H:S Hukommelsesklinikken, Neurologisk Klinik, H:S Rigshospitalet, København Ø.
Ugeskr Laeger. 2006 Oct 2;168(40):3424-9.
In Denmark, Alzheimer drugs have been registered since 1997. Three cholinesterase inhibitors (donepezil, rivastigmin og galantamin) are approved mild to moderate Alzheimer's disease and one partial NMDA receptor antagonist (memantin) with the indication moderate to severe Alzheimer's disease. The treatment is symptomatic with a parallel shift of the course. The life expectancy does not seem to be altered. There is documented effect on the cholinesterase inhibitors of up to two years and for memantine for 6 months. New disease modifying agents are under clinical development.
在丹麦,自1997年起就已登记了治疗老年痴呆症的药物。三种胆碱酯酶抑制剂(多奈哌齐、卡巴拉汀和加兰他敏)被批准用于治疗轻度至中度老年痴呆症,一种部分性N-甲基-D-天冬氨酸(NMDA)受体拮抗剂(美金刚)用于治疗中度至重度老年痴呆症。这种治疗是对症治疗,可使病程平行推移。预期寿命似乎并未改变。有记录表明胆碱酯酶抑制剂的疗效可持续长达两年,美金刚的疗效可持续6个月。新的疾病修饰药物正在临床研发中。