Renoux J, Facon D, Fillard P, Huynh I, Lasjaunias P, Ducreux D
Department of Neuroradiology, CHU de Bicêtre, Le Kremlin Bicêtre, France.
AJNR Am J Neuroradiol. 2006 Oct;27(9):1947-51.
Our aim was to study the fractional anisotropy (FA) variations and the fiber tracking (FT) patterns observed in patients with myelitis.
Fifteen patients with symptomatic myelitis and 11 healthy subjects were prospectively selected. We performed T2-weighted and diffusion tensor imaging on a 1.5T MR scanner. FA and apparent diffusion coefficient maps were computed in both healthy subjects and patients. In each patient, we performed FT to study pathologic aspects on this imaging method. FA data were analyzed by using z-scores.
For the healthy subjects, averaged FA values ranged from 0.745 to 0.751. All abnormal areas seen on T2-weighted imaging had a significantly decreased FA value. In 9 patients (60%), FA maps showed decreased FA areas, whereas T2-weighted imaging findings were normal. These areas matched the neurologic deficit in 33%. Eighty percent of patients had multiple decreased FA areas. Five patients (33%) had increased FA values in normal T2-weighted areas.
We observed specific FA and FT pattern variations in patients with myelitis.
我们的目的是研究脊髓炎患者中观察到的分数各向异性（FA）变化和纤维追踪（FT）模式。
前瞻性地选取了15例有症状的脊髓炎患者和11名健康受试者。我们在1.5T磁共振成像扫描仪上进行了T2加权和扩散张量成像。在健康受试者和患者中均计算了FA和表观扩散系数图。在每位患者中，我们进行了FT以研究这种成像方法的病理情况。通过使用z分数分析FA数据。
对于健康受试者，平均FA值范围为0.745至0.751。T2加权成像上所见的所有异常区域的FA值均显著降低。在9例患者（60%）中，FA图显示FA值降低区域，而T2加权成像结果正常。这些区域在33%的患者中与神经功能缺损相匹配。80%的患者有多个FA值降低区域。5例患者（33%）在T2加权正常区域的FA值升高。
我们观察到脊髓炎患者中特定的FA和FT模式变化。
