Saida Toshiaki
Dept. of Dermatology, Shinshu University School of Medicine.
Gan To Kagaku Ryoho. 2006 Oct;33(10):1386-91.
The definition of the TNM classification and staging system of malignant melanoma have been fundamentally revised. Moreover, several clinical guidelines for the management of this neoplasm were recently proposed. Advances in surgical procedures are excision of primary lesions with narrow margin and introduction of sentinel node biopsy, which contribute to maintain the good quality of life of patients. The significance of high-dose interferon-alpha as adjuvant therapy is still controversial. No effective chemotherapy or biotherapy has been established to date, however, interesting new findings were recently reported in the fields of immunotherapy and molecular targeting therapy.
恶性黑色素瘤的TNM分类及分期系统的定义已得到根本性修订。此外，最近还提出了几项针对该肿瘤治疗的临床指南。外科手术的进展包括采用窄切缘切除原发性病灶以及引入前哨淋巴结活检，这些有助于维持患者的良好生活质量。高剂量α干扰素作为辅助治疗的意义仍存在争议。迄今为止，尚未确立有效的化疗或生物治疗方法，不过，免疫治疗和分子靶向治疗领域最近报告了一些有趣的新发现。
