Carucci D J, Gardner M J, Tettelin H, Cummings L M, Smith H O, Adams M D, Venter J C, Hoffman S L
Malaria Program, Naval Medical Research Institute, 8901 Wisconsin Avenue, Bethesda, MD 20889, USA.
Curr Opin Infect Dis. 1998 Oct;11(5):531-4. doi: 10.1097/00001432-199810000-00003.
Advances in microbial genomic sequencing have the potential to revolutionize the control of infectious diseases. Recently, a consortium of researchers and funding agencies from the United States and Great Britain have embarked on a project to sequence the genome from Plasmodium falciparum, the most important cause of human malaria. The Malaria Genome Sequencing Project has reached an important milestone with the completion of the entire DNA sequence and annotation of chromosome 2, a 950 kilobase chromosome of Plasmodium falciparum. This review article will provide an overview of the malaria genome sequencing project, highlight progress in the field of microbial sequencing, and suggest new directions for future malaria research.
微生物基因组测序技术的进步有可能彻底改变传染病的防控方式。最近，来自美国和英国的一个由研究人员与资助机构组成的联盟启动了一个项目，对恶性疟原虫的基因组进行测序，恶性疟原虫是人类疟疾最重要的病因。随着恶性疟原虫一条950千碱基的2号染色体的完整DNA序列测定及注释工作的完成，疟疾基因组测序项目达到了一个重要的里程碑。这篇综述文章将概述疟疾基因组测序项目，突出微生物测序领域的进展，并为未来的疟疾研究提出新的方向。
