Orlando R, Tosone G, Tiseo D, Piazza M, Portella G, Ciancia R, Martinelli V, Montante B, Rotoli B
Dept. of Public Medicine and Social Security, Section of Infectious Diseases, University of Naples Federico II, Via Sergio Pansini 5, 80131, Naples, Italy.
Infection. 2006 Oct;34(5):282-4. doi: 10.1007/s15010-006-4150-8.
The reverse seroconversion to hepatitis B virus infection has been sporadically described in onco-haematological patients receiving cytotoxic therapy or allogeneic bone marrow transplantation and can be associated with the development of acute icteric hepatitis. We present a male HBsAg-negative, anti-HBc-positive patient with Hairy Cell Leukemia who developed acute B hepatitis more than 1 year after the last course of 2-CdA and 6 months after splenectomy, while the patient was receiving therapy with alphaIFNr. The acute B hepatitis promptly responded to lamivudine therapy followed by viral clearance.
