Reuther Cordula, Hajdo Lukasz, Tucker Robert, Kasprzak Andrzej A, Diez Stefan
Max-Planck-Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany.
Nano Lett. 2006 Oct;6(10):2177-83. doi: 10.1021/nl060922l.
We report on the generation of nanometer-wide, non-topographical patterns of proteins on planar surfaces. In particular, we used the regular lattice of reconstituted microtubules as template structures to specifically bind and transfer kinesin-1 and nonclaret disjunctional motor proteins. The generated tracks, which comprise dense and structurally oriented arrays of functional motor proteins, proved to be highly efficient for the guiding of microtubule transporters.
我们报道了在平面表面上生成纳米级宽的蛋白质非形貌图案。具体而言，我们利用重组微管的规则晶格作为模板结构，特异性地结合并转移驱动蛋白-1和非红葡萄酒不分离运动蛋白。所生成的轨道由密集且结构定向的功能性运动蛋白阵列组成，事实证明对微管转运体具有高效的导向作用。
