Wittgen Bart P H, Kunst Peter W A, Perkins Walter R, Lee Jin K, Postmus Pieter E
Department of Pulmonary Diseases, VU University Medical Center, Amsterdam, The Netherlands.
J Aerosol Med. 2006 Fall;19(3):385-91. doi: 10.1089/jam.2006.19.385.
The aim of this study was to determine the efficacy of using a high-efficiency particulate air (HEPA) filter air cleaning system, a demistifier, to reduce the potential risk of fugitive aerosol contact in health care personnel working with patients inhaling nebulized liposomal encapsulated SLIT (Sustained-release Lipid Inhalation Targeting) Cisplatin. Filters were used to sample platinum in the air outside the tent and from the tent's exhaust stream. Air collection was performed under three conditions: (1) during patient dosing (14 h of air collection); (2) immediately after the patient has left the demistifier tent (4 h of air collection); and (3) when 7 mL of drug product was nebulized to dryness in the tent without a patient being present. Filters were collected, and placed in an extraction solvent. Subsequently, the solvent was assayed for platinum content by inductively coupled plasma-mass spectrometry (ICP-MS). Platinum levels in the extraction solvent were indistinguishable from the blank controls for all conditions. Measured levels were below workplace exposure limits established for cisplatin by the Occupational Safety and Health Administration (i.e., 2 ng . (L(1)). In addition, the demistifier was able to effectively capture aerosolized SLIT Cisplatin following nebulization of 7 mL of drug product to dryness in the tent. The demistifier tent is effective at containing any nebulized liposomal encapsulated cisplatin during patient treatment. Importantly, because the tent's HEPA filtration system is effective at removing any nebulized liposomal cisplatin, the exhausted air, which is free of platinum, can be returned into the room with no additional ventilation precautions.
本研究的目的是确定使用高效空气过滤器（HEPA）空气净化系统（一种除雾器）来降低医护人员在为吸入雾化脂质体包裹的缓释脂质吸入靶向顺铂（SLIT Cisplatin）的患者治疗时发生意外气溶胶接触潜在风险的效果。使用过滤器对帐篷外空气和帐篷排气流中的铂进行采样。在三种条件下进行空气收集：（1）患者给药期间（收集14小时空气）；（2）患者离开除雾器帐篷后立即进行（收集4小时空气）；（3）在帐篷内无患者的情况下将7毫升药品雾化至干燥。收集过滤器并置于萃取溶剂中。随后，通过电感耦合等离子体质谱法（ICP-MS）测定溶剂中的铂含量。在所有条件下，萃取溶剂中的铂水平与空白对照无差异。测量水平低于美国职业安全与健康管理局规定的顺铂工作场所暴露限值（即2纳克·升⁻¹）。此外，除雾器能够在帐篷内将7毫升药品雾化至干燥后有效捕获雾化的SLIT顺铂。除雾器帐篷在患者治疗期间能够有效容纳任何雾化的脂质体包裹顺铂。重要的是，由于帐篷的HEPA过滤系统能够有效去除任何雾化的脂质体顺铂，不含铂的排出空气无需额外的通风预防措施即可返回室内。
