用于分析阿昔洛韦和盐酸醋丁洛尔的分光光度法和荧光分光光度法。
Spectrophotometric and spectrofluorimetric methods for analysis of acyclovir and acebutolol hydrochloride.
作者信息
Ayad Magda M, Abdellatef Hisham E, El-Henawee Magda M, El-Sayed Heba M
机构信息
Department of Analytical Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt.
出版信息
Spectrochim Acta A Mol Biomol Spectrosc. 2007 Jan;66(1):106-10. doi: 10.1016/j.saa.2006.02.031. Epub 2006 Feb 28.
Simple and sensitive spectrophotometric and spectrofluorimetric methods are described for analysis of acyclovir and acebutolol hydrochloride. The proposed methods are based on oxidation of the selected drugs with cerium(IV) ion in acidic medium with subsequent measurement of either the decrease in absorbance at 320nm or the fluorescence intensity of the produced cerous(III) ion at 361-363nm (excitation at 250nm). Beer's law obeyed from 2 to 8, 0.25 to 2.5microgcm-1 acyclovir, 1 to 7 and 0.25 to 2.5microgml-1 acebutolol hydrochloride, using the spectrophotometric and spectrofluorimetric method, respectively. The proposed method were successfully applied for determination of the selected drugs in their pharmaceutical preparations with good recoveries.
本文描述了用于分析阿昔洛韦和盐酸醋丁洛尔的简单且灵敏的分光光度法和荧光分光光度法。所提出的方法基于在酸性介质中用铈（IV）离子氧化所选药物，随后测量320nm处吸光度的降低或在361 - 363nm处产生的铈（III）离子的荧光强度（激发波长为250nm）。分别使用分光光度法和荧光分光光度法时，阿昔洛韦在2至8μg/cm³、盐酸醋丁洛尔在0.25至2.5μg/ml范围内符合比尔定律。所提出的方法成功应用于其药物制剂中所选药物的测定，回收率良好。
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