Gross G E, Schumann J
Universitäts-Hautklinik Hamburg-Eppendorf.
Hautarzt. 1990 Nov;41(11):591-601.
Specific antivirals like acyclovir have ameliorated the outcome of severe herpesvirus infections, especially in immunocompromised patients. Varicella can be prevented in high-risk patients after exposure by therapy with varicella-zoster immunoglobulin. Despite this favorable development, there are many unresolved problems in the management of herpesvirus infections, such as the use of acyclovir during pregnancy, the treatment of both motoric neuropathy and postherpetic neuralgia. Chemotherapy-resistant herpesvirus may cause severe syndromes in patients suffering from HIV infection or from iatrogenic immunosuppression. Isolation of resistant viruses provides the stimulus to establish tests of viral resistance and to use antiviral drugs more carefully.
像阿昔洛韦这样的特效抗病毒药物改善了严重疱疹病毒感染的治疗效果，尤其是在免疫功能低下的患者中。接触水痘后，高危患者可通过使用水痘-带状疱疹免疫球蛋白进行治疗来预防感染。尽管有了这样良好的进展，但疱疹病毒感染的治疗仍存在许多未解决的问题，例如孕期使用阿昔洛韦、运动性神经病变和带状疱疹后神经痛的治疗。对化疗耐药的疱疹病毒可能在感染HIV或医源性免疫抑制的患者中引发严重综合征。耐药病毒的分离促使人们建立病毒耐药性检测方法，并更谨慎地使用抗病毒药物。
