完成四种去甲烟碱衍生物的¹H和¹³C NMR光谱数据。

Complete assignments 1H and 13C NMR spectral data of four anabaseine derivatives.

作者信息

Sobarzo-Sánchez Eduardo, De la Fuente Julio, Quezada Elías, Castedo Luis

机构信息

Department of Organic Chemistry and C.S.I.C. Associated Unit, Faculty of Chemistry, University of Santiago de Compostela, 15782, Santiago de Compostela, Spain.

出版信息

Magn Reson Chem. 2006 Dec;44(12):1131-4. doi: 10.1002/mrc.1911.

DOI:10.1002/mrc.1911

PMID:17036372

Abstract

The anabaseine derivatives 6-methoxy-7-hydroxy-1-(pyridin-3-yl)-3,4-dihydroisoquinoline, 6,7-dimethoxy-1-(pyridin-3-yl)-1,2,3,4-tetrahydroisoquinoline and 6,7-dimethoxy-1-(piperidin-3-yl)-1,2,3,4-tetrahydroisoquino- line were prepared either by demethylation with HBr or by reduction with different reagents, NaBH4 and H2/PtO2 from 6,7-dimethoxy-1-(pyridin-3-yl)-3,4-dihydroisoquinoline, as starting material. The structures have been fully assigned by the combination of one- and two-dimensional experiments.

摘要

以6,7-二甲氧基-1-(吡啶-3-基)-3,4-二氢异喹啉为起始原料，通过用HBr脱甲基或用不同试剂（NaBH4和H2/PtO2）还原制备了阿那贝碱衍生物6-甲氧基-7-羟基-1-(吡啶-3-基)-3,4-二氢异喹啉、6,7-二甲氧基-1-(吡啶-3-基)-1,2,3,4-四氢异喹啉和6,7-二甲氧基-1-(哌啶-3-基)-1,2,3,4-四氢异喹啉。通过一维和二维实验相结合的方式对结构进行了完全归属。