Bleeker F E, van Furth W R, van der Horst C M A M, Majoie C B L M, Koot R W
Academisch Medisch Centrum/Universiteit van Amsterdam.
Ned Tijdschr Geneeskd. 2006 Sep 23;150(38):2061-6.
Three patients, aged 2, 2.5 and 24 years, presented with a skin lesion in the median or paramedian area at the nose, in the lumbar region and between the shoulders, respectively. The first patient suffered from recurrent infection, the skin lesion of the second patient was a coincidental finding, and the third patient had cosmetic problems. Although there were no signs of neurological deficits, neurodermal closing defects were found by MRI. Two patients underwent surgery to prevent infection and neurological complaints in the future. It is stressed that even if there are no neurological signs or infections, congenital dermal lesions situated in the midline should be considered as possible neural tube defects and therefore analysed by MRI. Ifa neurodermal dysraphism is found, patients should be referred to a neurosurgical centre. A good clinical assessment of the neural lesion, clinical signs and age will determine whether surgical resection is indicated to prevent or resolve neurological problems, infections or cosmetic complaints.
三名患者，年龄分别为2岁、2.5岁和24岁，分别在鼻子的正中或旁正中区域、腰部以及双肩之间出现皮肤病变。第一名患者患有反复感染，第二名患者的皮肤病变是偶然发现的，第三名患者存在美容问题。尽管没有神经功能缺损的体征，但通过磁共振成像（MRI）发现了神经皮肤闭合缺陷。两名患者接受了手术，以预防未来的感染和神经方面的问题。需要强调的是，即使没有神经体征或感染，位于中线的先天性皮肤病变也应被视为可能的神经管缺陷，因此需通过MRI进行分析。如果发现神经皮肤发育异常，患者应被转诊至神经外科中心。对神经病变、临床体征和年龄进行良好的临床评估，将决定是否需要进行手术切除以预防或解决神经问题、感染或美容方面的问题。
