在转化的非允许性仓鼠细胞和鸡细胞的异核体中激活的劳斯病毒上存在鸡细胞表面抗原。
Presence of chicken cell surface antigen on Rous virus activated in heterokaryons of transformed non-permissive hamster cells and chicken cells.
作者信息
Vigier P, Aupoix M
出版信息
J Gen Virol. 1975 Aug;28(2):265-9. doi: 10.1099/0022-1317-28-2-265.
Incubation with antiserum to chick embryo (CE) cells, in the presence of complement, inactivates Rous sarcoma virus (RSV) produced by heterokaryons formed by non-permissive RSV-transformed hamster cells and CE cells as well as RSV produced by heterokaryons is observed following incubation with antiserum to the transformed hamster cells, plus complement. Hence, the envelope of RSV activated in heterokaryons, as that of RSV produced by CE cells, must contain a surface antigen of the CE cell, and the virus must mature only, or preferentially, at chicken-specific sites of the heterokaryon surface.
在补体存在的情况下，用抗鸡胚（CE）细胞的抗血清孵育，可使由非允许性劳斯肉瘤病毒（RSV）转化的仓鼠细胞与CE细胞形成的异核体产生的RSV失活，并且在用抗转化仓鼠细胞的抗血清加补体孵育后，也观察到异核体产生的RSV失活。因此，在异核体中被激活的RSV的包膜，如同CE细胞产生的RSV的包膜一样，必定含有CE细胞的一种表面抗原，并且该病毒必定仅在异核体表面的鸡特异性位点成熟，或者优先在这些位点成熟。
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